2025 NDC/HCPCS Crosswalk


The NDC/HCPCS Crosswalk file provides a list of National Drug Codes (NDC) linked to Level II HCPCS codes, including pricing conversion factors for billable claims submitted to the DME MACs. This crosswalk enables the processing of claims using the NCPDP format. It includes prescription drugs administered in a home setting that are eligible for reimbursement under the DMEPOS benefit.

The PDAC updates the crosswalk monthly to add, revise, or delete NDCs as published in the RED BOOK drug compendium. The prepared NDC/HCPCS Crosswalk files below outline these updates and changes.

For NDC/HCPCS crosswalk questions, view our NDC/HCPCS Crosswalk FAQs and Definitions.

 

October 2025

NDC to HCPCS Crosswalk (Excel, 1462 KB)
NDC to HCPCS Crosswalk (PDF, 2927 KB)
Date Changes (PDF, 287 KB)
Coding Changes (PDF, 81 KB)
Conversion Factor Changes (PDF, 76 KB)
Records and NDCs Added (PDF, 120 KB)
Records and NDCs Removed (PDF, 92 KB)
Additional Changes (PDF, 73 KB)

September 2025

NDC to HCPCS Crosswalk (Excel, 1170 KB)
NDC to HCPCS Crosswalk (PDF, 2902 KB)
Date Changes (PDF, 85 KB)
Coding Changes (PDF, 74 KB)
Conversion Factor Changes (PDF, 79 KB)
Records and NDCs Added (PDF, 95 KB)
Records and NDCs Removed (PDF, 83 KB)
Additional Changes (PDF, 76 KB)

August 2025

NDC to HCPCS Crosswalk (Excel, 1170 KB)
NDC to HCPCS Crosswalk (PDF, 2827 KB)
Date Changes (PDF, 33 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 30 KB)
Records and NDCs Removed (PDF, 9 KB)
Additional Changes (PDF, 9 KB)

July 2025

NDC to HCPCS Crosswalk (Excel, 1166 KB)
NDC to HCPCS Crosswalk (PDF, 2813 KB)
Date Changes (PDF, 19 KB)
Coding Changes (PDF, 47 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 49 KB)
Records and NDCs Removed (PDF, 14 KB)
Additional Changes (PDF, 9 KB)

June 2025

NDC to HCPCS Crosswalk (Excel, 1145 KB)
NDC to HCPCS Crosswalk (PDF, 2772 KB)
Date Changes (PDF, 31 KB)
Coding Changes (PDF, 10 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 26 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 9 KB)

May 2025

NDC to HCPCS Crosswalk (Excel, 1141 KB)
NDC to HCPCS Crosswalk (PDF, 2766 KB)
Date Changes (PDF, 14 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 29 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 9 KB)

April 2025

NDC to HCPCS Crosswalk (Excel, 1142 KB)
NDC to HCPCS Crosswalk (PDF, 2759 KB)
Date Changes (PDF, 25 KB)
Coding Changes (PDF, 36 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 53 KB)
Records and NDCs Removed (PDF, 12 KB)
Additional Changes (PDF, 9 KB)

March 2025

NDC to HCPCS Crosswalk (Excel, 1122 KB)
NDC to HCPCS Crosswalk (PDF, 2721 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 24 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 9 KB)

February 2025

NDC to HCPCS Crosswalk (Excel, 1119 KB)
NDC to HCPCS Crosswalk (PDF, 2714 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 25 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 9 KB)

January 2025

NDC to HCPCS Crosswalk (Excel, 1121 KB)
NDC to HCPCS Crosswalk (PDF, 2709 KB)
Date Changes (PDF, 19 KB)
Coding Changes (PDF, 45 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 65 KB)
Records and NDCs Removed (PDF, 17 KB)
Additional Changes (PDF, 9 KB)

Last Updated: 10/01/2025